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They are not only mediators of intracellular communication but also have been associated with many inflammatory pathways associated with disease including autoinflammatory conditions such as obesity and Type II diabetes (123, 124), as well as autoimmune disease such as rheumatoid arthritis (125, 126), neurodegenerative disorders such as Alzheimer's disease (127) and cancer (128)

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The compound progressed through Phase 2 trials under multiple sponsors for postoperative ileus and related gastric-motility indications but did not advance to a marketed therapeutic

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